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1

mTOR mediated anti-cancer drug discovery

Qingsong Liu, Carson Thoreen, Jinhua Wang, David Sabatini, Nathanael S. Gray

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2009

Language:

english

File:

PDF, 467 KB

english, 2009

2

Thomas Pynchon's Political Parable: Parallels between Vineland and “Rip Van Winkle”

Journal:

ANQ A Quarterly Journal of Short Articles Notes and Reviews

Year:

2001

Language:

english

File:

PDF, 383 KB

english, 2001

3

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

Qingsong Liu, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Wooyoung Hur, Hwan Geun Choi, David L. Waller, Taebo Sim, David M. Sabatini, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

4

Huntingtin aggregates ask to be eaten

Thoreen, Carson C, Sabatini, David M

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 90 KB

english, 2004

5

A unifying model for mTORC1-mediated regulation of mRNA translation

Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.

Journal:

Year:

2012

Language:

english

File:

PDF, 936 KB

english, 2012

6

Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division

David A. Guertin, Kalyani V.P. Guntur, George W. Bell, Carson C. Thoreen, David M. Sabatini

Journal:

Current Biology

Year:

2006

Language:

english

File:

PDF, 907 KB

english, 2006

7

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Maria A. Frias, Carson C. Thoreen, Jacob D. Jaffe, Wayne Schroder, Tom Sculley, Steven A. Carr, David M. Sabatini

Journal:

Current Biology

Year:

2006

Language:

english

File:

PDF, 399 KB

english, 2006

8

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

Timothy R. Peterson, Mathieu Laplante, Carson C. Thoreen, Yasemin Sancak, Seong A. Kang, W. Michael Kuehl, Nathanael S. Gray, David M. Sabatini

Journal:

Year:

2009

Language:

english

File:

PDF, 2.00 MB

english, 2009

9

AMPK and p53 help cells through lean times

Carson C. Thoreen, David M. Sabatini

Journal:

Cell Metabolism

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

10

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen, Aurora A. Burds, Nada Y. Kalaany, Jason Moffat, Michael Brown, Kevin J. Fitzgerald, David M. Sabatini

Journal:

Developmental Cell

Year:

2006

Language:

english

File:

PDF, 1.92 MB

english, 2006

11

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

Yasemin Sancak, Carson C. Thoreen, Timothy R. Peterson, Robert A. Lindquist, Seong A. Kang, Eric Spooner, Steven A. Carr, David M. Sabatini

Journal:

Year:

2007

Language:

english

File:

PDF, 1.65 MB

english, 2007

12

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[ h ][1,6]naphthyridin-2(1 H )-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

13

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1 H )-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.22 MB

english, 2010

14

Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

15

Loss of protein synthesis quality control in host-restricted organisms

Melnikov, Sergey V., van den Elzen, Antonia, Stevens, David L., Thoreen, Carson C., Söll, Dieter

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 4.04 MB

english, 2018

16

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen, Carson C., Kang, Seong A., Chang, Jae Won, Liu, Qingsong, Zhang, Jianming, Gao, Yi, Reichling, Laurie J., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 240 KB

2020

17

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2020

File:

PDF, 927 KB

2020